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KMID : 0370220230670030176
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Yakhak Hoeji
2023 Volume.67 No. 3 p.176 ~ p.181
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TEC Genetic Polymorphism is Associated with TNF-α Inhibitor Treatment Response in Rheumatoid Arthritis Patients
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Kim Jun-Hyeob
Kim Woo-Rim
Gil Jin-Yeon
Min Kyung-Hyun
Han Ji-Min
Lee Kyung-Eun
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Abstract
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Numerous genetic and clinical factors influence the progression of rheumatoid arthritis and treatment response.
Single nucleotide polymorphisms (SNPs) have been associated with different treatment responses in TNF-α inhibitor users.
This study aimed to determine if Tec protein tyrosine kinase (TEC), which belongs to the Tec family of non-receptorprotein tyrosine kinases, is associated with treatment response in rheumatoid arthritis (RA) patients. RA patients from threeuniversity hospitals were recruited, and clinical data were collected from electronic medical records. One hundred fourteenpatients treated with TNF-α inhibitor were included in the analysis. SNP-response associations were evaluated usinglogistic regression. Among the five SNPs analyzed, rs1472971 and rs11727166 were statistically significant genetic factorsof TNF-α inhibitor treatment response. This study provides genetic evidence that TEC polymorphism can be a prognosticmarker in treating RA patients.
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KEYWORD
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Rheumatoid arthritis, TNF-α inhibitor, Single nucleotide polymorphism, Tec protein tyrosine kinase
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